Publications scientifiques

19
Nov 2025
10:18 E.S.T.

Circular single stranded DNA potentiates non-viral gene insertion in hematopoietic stem and progenitor cells

Gil Letort, Aymeric Duclert, Diane Le Clerre, Isabelle Chion-Sotinel, Roger Salvatori, Emilie Dessez, Margaux Sevin, Marco Rotondi, Cosimo Ducani, Philippe Duchateau & Julien Valton
Nature Communications
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3
Sep 2024
15:12 E.S.T.

Multi-armored allogeneic MUC1 CAR T cells enhance efficacy and safety in triple-negative breast cancer

Piril Erler, Tomasz Kurcon, Hana Cho, Jordan Skinner, Chantel Dixon, Steven Grudman, Sandra Rozlan, Emilie Dessez, Ben Mumford, Sumin Jo, Alex Boyne, Beatriz Aranda-Orgilles, Alexandre Juillerat, Philippe Duchateau et Laurent Poirot
Science Advances
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26
Août 2024
14:41 E.S.T.

TALEN-edited Allogeneic Inducible Dual CAR T-cells Enable Effective Targeting of Solid Tumors while Mitigating Off-Tumor Toxicity

Sonal Dharani, Hana Cho, Jorge Postigo Fernandez, Alexandre Juillerat, Julien Valton, Philippe Duchateau, Laurent Poirot et Shipra Das
Molecular Therapy
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20
Juin 2024
20:30 E.S.T.

Comprehensive analysis of the editing window of C-to-T TALE base editors

Maria Feola, Sylvain Pulicani, Diane Tkach, Alex Boyne, Robert Hong, Louisa Mayer, Aymeric Duclert, Philippe Duchateau & Alexandre Juillerat
Scientific Reports
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12
Juin 2024
14:41 E.S.T.

Non-viral DNA delivery and TALEN editing correct the sickle cell mutation in hematopoietic stem cells

Arianna Moiani, Gil Letort, Sabrina Lizot, Chloé Foray, Diane Le Clerre, Sonal Temburni-Blake, Patrick Hong, Sophie Leduc, Noémie Pinard, Alan Marechal, Eduardo Seclen, Alex Boyne, Louisa Mayer, Anne Chalumeau, Tristan Felix, Robert Hong, Sylvain Pulicani, Roman Galetto, Agnès Gouble, Marina Cavazzana, Alexandre JUillerat, Annarita Miccio, Aymeric Duclert, Philippe Duchateau & Julien Valton
Nature Communications
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10
Avr 2024
14:32 E.S.T.

TALEN-mediated intron editing of HSPCs enables transgene expression restricted to the myeloid lineage

Julien Valton, Philippe Duchateau, Alexandre Juillerat, Alex Boyne, Eduardo Seclen, Jessica C. Jang, Aminah O.Lawal, Sylvain Pulicani and Diane Tkach
Molecular Therapy
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31
Mai 2023
20:38 E.S.T.

Preclinical Evidence of an Allogeneic Dual CD20xCD22 CAR to Target a Broad Spectrum of Patients with B-cell Malignancies

Beatriz Aranda-Orgilles ; Isabelle Chion-Sotinel ; Jordan Skinner ; Steven Grudman ; Ben Mumford ; Chantel Dixon ; Jorge Postigo Fernandez ; Piril Erler ; Phillipe Duchateau ; Agnes Gouble ; Roman Galetto ; Laurent Poirot
Cancer Immunology Research
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12
Mai 2023
08:57 E.S.T.

Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy

Shipra Das, Julien Valton, Philippe Duchateau, Laurent Poirot
Frontiers in Immunology
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10
Nov 2022
11:11 E.S.T.

Efficient multitool/multiplex gene engineering with TALE-BE

Alex Boyne, Alexandre Juillerat, Sylvain Pulicani, Maria Feola, Diane Tkach, Robert Hong, Aymeric Duclert, Philippe Duchateau
Frontiers in Bioengineering and Biotechnology
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30
Juin 2022
13:43 E.S.T.

https://www.nature.com/articles/s41467-022-30896-2

Julien Valton, Shipra Das, Siumin Jo
Nature Communications
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