Scientific publications

Straightforward Generation of Ultrapure Off-the-Shelf Allogeneic CAR-T Cells

Alexandre Juillerat, Diane Tkach, Ming Yang, Alex Boyne, Julien Valton, Laurent Poirot and Philippe Duchateau
Frontiers in Bioengineering and Biotechnology June 25, 2020
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Allogeneic FLT3 CAR T cells with an off-switch exhibit potent activity against acute myeloid leukemia and can be depleted to expedite bone marrow recovery

Cesar Sommer, Hsin-Yuan Cheng, Duy Nguyen, Danielle Dettling, Yik Andy Yeung, Janette Sutton, Moustafa Hamze, Julien Valton, Julianne Smith, Ivana Djuretic, Javier Chaparro-Riggers, Barbra J. Sasu
Molecular Therapy June 15, 2020
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Off-the-shelf allogeneic CAR T cells: new development and current challenges

S. Depil, P. Duchateau, S. A. Grupp, G. Mufti and L. Poirot
Nature Review Drug Discovery January 3, 2020
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Repurposing Endogenous Immune Pathways to Tailor and Control Chimeric Antigen Receptor T-cell Functionality

Mohit Sachdeva, Brian W. Busser, Sonal Temburni, Billal Jahangiri, Anne-Sophie Gautron, Alan Maréchal, Alexandre Juillerat, Alan Williams, Stéphane Depil, Philippe Duchateau, Laurent Poirot and Julien Valton
Nature Communications November 2019
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Modulation of Chimeric Antigen Receptor surface expression by a small molecule switch

Alexandre Juillerat, Diane Tkach, Brian W. Busser, Sonal Temburni, Julien Valton, Aymeric Duclert, Laurent Poirot, Stéphane Depil and Philippe Duchateau
BMC Biotechnology (2019); Published Online:
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