15 Jun 2020
11:29 E.S.T.

Allogeneic FLT3 CAR T cells with an off-switch exhibit potent activity against acute myeloid leukemia and can be depleted to expedite bone marrow recovery

Cesar Sommer, Hsin-Yuan Cheng, Duy Nguyen, Danielle Dettling, Yik Andy Yeung, Janette Sutton, Moustafa Hamze, Julien Valton, Julianne Smith, Ivana Djuretic, Javier Chaparro-Riggers, Barbra J. Sasu
Molecular Therapy June 15, 2020

03 Jan 2020
09:42 E.S.T.

Off-the-shelf allogeneic CAR T cells: new development and current challenges

S. Depil, P. Duchateau, S. A. Grupp, G. Mufti and L. Poirot
Nature Review Drug Discovery January 3, 2020

19 Nov 2019
10:55 E.S.T.

Repurposing Endogenous Immune Pathways to Tailor and Control Chimeric Antigen Receptor T-cell Functionality

Mohit Sachdeva, Brian W. Busser, Sonal Temburni, Billal Jahangiri, Anne-Sophie Gautron, Alan Maréchal, Alexandre Juillerat, Alan Williams, Stéphane Depil, Philippe Duchateau, Laurent Poirot and Julien Valton
Nature Communications November 2019

08 Jul 2019
11:13 E.S.T.

Modulation of Chimeric Antigen Receptor surface expression by a small molecule switch

Alexandre Juillerat, Diane Tkach, Brian W. Busser, Sonal Temburni, Julien Valton, Aymeric Duclert, Laurent Poirot, Stéphane Depil and Philippe Duchateau
BMC Biotechnology (2019); Published Online: https://doi.org/10.1186/s12896-019-0537-3

25 Feb 2019
17:56 E.S.T.

Granulocyte-macrophage colony-stimulating factor inactivation in CAR T-Cells prevents monocyte-dependent release of key cytokine release syndrome mediators

Mohit Sachdeva, Philippe Duchateau, Stéphane Depil, Laurent Poirot and Julien Valton
Journal of Biological Chemistry; Published Online: doi: 10.1074/jbc.AC119.007558

06 Jul 2018
11:53 E.S.T.

Understanding the indirect DNA read-out specificity of I-CreI Meganuclease

Jesús Prieto, Pilar Redondo, Blanca López-Méndez, Marco D’Abramo, Nekane Merino, Francisco J. Blanco, Phillipe Duchateau, Guillermo Montoya & Rafael Molina
Scientific Reportsvolume 8, Article number: 10286 (2018) July 6, 2018

12 Jun 2018
05:00 E.S.T.

A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies

Julien Valton, Valerie Guyot, Bijan Boldajipour, Cesar Sommer, Thomas Pertel, Alexandre Juillerat, Aymeric Duclert, Barbra Johnson Sasu, Philippe Duchateau & Laurent Poirot
Scientific Reportsvolume 8, Article number: 8972 (2018) June 12, 2018

20 Nov 2017
16:36 E.S.T.

Fine and predictable tuning of TALEN gene editing targeting for improved T-cell adoptive immunotherapy

Anne-Sophie Gautron, Alexandre Juillerat, Valérie Guyot, Jean-Marie Filhol, Emilie Dessez, Aymeric Duclert, Philippe Duchateau and Laurent Poirot
Molecular Therapy - Nucleic Acids Volume 9, December 15, 2017

30 Jan 2017
12:37 E.S.T.

Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells

Francesca Stillitano, Jens Hansen, Chi-Wing Kong, Ioannis Karakikes, Christian Funck-Brentano, Lin Geng, Stuart Scott, Stephan Reynier, Ma Wu, Yannick Valogne, Carole Desseaux, Joe-Elie Salem, Dorota Jeziorowska, Noël Zahr, Ronald Li, Ravi Iyengar, Roger J Hajjar, Jean-Sébastien Hulot
Elife. 2017 Jan 30

20 Jan 2017
08:05 E.S.T.

An oxygen sensitive self-decision making engineered CAR T-cell

Alexandre Juillerat, Alan Marechal, Jean Marie Filhol, Yannick Valogne, Julien Valton, Aymeric Duclert, Philippe Duchateau and Laurent Poirot
Scientific Reports 7, Article number: 39833 (2017) doi:10.1038/srep39833

Scientific publications

Allogeneic FLT3 CAR T cells with an off-switch exhibit potent activity against acute myeloid leukemia and can be depleted to expedite bone marrow recovery

Off-the-shelf allogeneic CAR T cells: new development and current challenges

Repurposing Endogenous Immune Pathways to Tailor and Control Chimeric Antigen Receptor T-cell Functionality

Modulation of Chimeric Antigen Receptor surface expression by a small molecule switch

Granulocyte-macrophage colony-stimulating factor inactivation in CAR T-Cells prevents monocyte-dependent release of key cytokine release syndrome mediators

Understanding the indirect DNA read-out specificity of I-CreI Meganuclease

A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies

Fine and predictable tuning of TALEN gene editing targeting for improved T-cell adoptive immunotherapy

Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells

An oxygen sensitive self-decision making engineered CAR T-cell