Publications scientifiques

Off-the-shelf allogeneic CAR T cells: new development and current challenges

S. Depil, P. Duchateau, S. A. Grupp, G. Mufti and L. Poirot
Nature Review Drug Discovery January 3, 2020
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Repurposing Endogenous Immune Pathways to Tailor and Control Chimeric Antigen Receptor T-cell Functionality

Mohit Sachdeva, Brian W. Busser, Sonal Temburni, Billal Jahangiri, Anne-Sophie Gautron, Alan Maréchal, Alexandre Juillerat, Alan Williams, Stéphane Depil, Philippe Duchateau, Laurent Poirot and Julien Valton
Nature Communications November 2019
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Modulation of Chimeric Antigen Receptor surface expression by a small molecule switch

Alexandre Juillerat, Diane Tkach, Brian W. Busser, Sonal Temburni, Julien Valton, Aymeric Duclert, Laurent Poirot, Stéphane Depil and Philippe Duchateau
BMC Biotechnology (2019); Published Online: https://doi.org/10.1186/s12896-019-0537-3
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Granulocyte-macrophage colony-stimulating factor inactivation in CAR T-Cells prevents monocyte-dependent release of key cytokine release syndrome mediators

Mohit Sachdeva, Philippe Duchateau, Stéphane Depil, Laurent Poirot and Julien Valton
Journal of Biological Chemistry; Published Online: doi: 10.1074/jbc.AC119.007558
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Understanding the indirect DNA read-out specificity of I-CreI Meganuclease

Jesús Prieto, Pilar Redondo, Blanca López-Méndez, Marco D’Abramo, Nekane Merino, Francisco J. Blanco, Phillipe Duchateau, Guillermo Montoya & Rafael Molina
Scientific Reportsvolume 8, Article number: 10286 (2018) 6 juillet 2018
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A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies

Julien Valton, Valerie Guyot, Bijan Boldajipour, Cesar Sommer, Thomas Pertel, Alexandre Juillerat, Aymeric Duclert, Barbra Johnson Sasu, Philippe Duchateau & Laurent Poirot
Scientific Reportsvolume 8, Article number: 8972 (2018) June 12, 2018
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Fine and predictable tuning of TALEN gene editing targeting for improved T-cell adoptive immunotherapy

Anne-Sophie Gautron, Alexandre Juillerat, Valérie Guyot, Jean-Marie Filhol, Emilie Dessez, Aymeric Duclert, Philippe Duchateau and Laurent Poirot
Molecular Therapy - Nucleic Acids Volume 9, December 15, 2017
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Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells

Francesca Stillitano, Jens Hansen, Chi-Wing Kong, Ioannis Karakikes, Christian Funck-Brentano, Lin Geng, Stuart Scott, Stephan Reynier, Ma Wu, Yannick Valogne, Carole Desseaux, Joe-Elie Salem, Dorota Jeziorowska, Noël Zahr, Ronald Li, Ravi Iyengar, Roger J Hajjar, Jean-Sébastien Hulot
Elife. 2017 Jan 30
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