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Expression, purification, crystallization and preliminary X-ray diffraction analysis of the novel modular DNA-binding protein BurrH in its apo form and in complex with its target DNA

Stella S, Molina R, Bertonatti C, Juillerrat A, Montoya G.
Acta Crystallogr F Struct Biol Commun. 2014 Jan;70(Pt 1):87-91. doi: 10.1107/S2053230X13033037. Epub 2013 Dec 24.

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06 décembre 2013
09:08 E.S.T.

Can stem-cell-derived models revolutionize drug discovery?

Landgren H, Sartipy P.
Expert Opin Drug Discov. 2014 Jan;9(1):9-13. doi: 10.1517/17460441.2014.867945.

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26 novembre 2013
14:45 E.S.T.

megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering

Boissel S, Jarjour J, Astrakhan A, Adey A, Gouble A, Duchateau P, Shendure J, Stoddard BL, Certo MT, Baker D, Scharenberg AM.
Nucleic Acids Res. 2014 Feb;42(4):2591-601. doi: 10.1093/nar/gkt1224.

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13 novembre 2013
10:47 E.S.T.

Targeted gene therapy of Xeroderma Pigmentosum cells using meganucleases and TALEN™

Dupuy A, Valton J, Leduc S, Armier J, Galetto R, Gouble A, Lebuhotel C, Stary A, Pâques F, Duchateau P, Sarasin A, Daboussi F.
2013 Nov 13; DOI: 10.1371/journal.pone.0078678

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15 août 2013
10:53 E.S.T.

Structure of the AvrBs3-DNA complex provides new insights into the initial thymine-recognition mechanism

Stella S, Molina R, Yefimenko I, Prieto J, Silva G, Bertonati C, Juillerat A, Duchateau P, Montoya G.
Acta Crystallographica D Biological Crystallography 2013 Sep 1; 69(Pt 9):1707-16. doi: 10.1107/S0907444913016429

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01 août 2013
10:59 E.S.T.

Genome engineering with TAL-effector Nucleases and Alternative Modular Nuclease Technologies

Scharenberg AM, Duchateau P, Smith J.
Curr Gene Ther. 2013 Aug;13(4):291-303.

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12 juillet 2013
10:51 E.S.T.

Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells

Ulvestad M, Nordell P, Asplund A, Rehnström M, Jacobsson S, Holmgren G, Davidson L, Brolén G, Edsbagge J, Björquist P, Küppers-Munther B, Andersson TB.
Biochemical Pharmacology 2013 Sep 1; 86(5):691-702. doi: 10.1016/j.bcp.2013.06.029.

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07 juillet 2013
19:00 E.S.T.

A Novel 3D Label-Free Monitoring System of hES-Derived Cardiomyocyte Clusters: A Step Forward to In Vitro Cardiotoxicity Testing

Jahnke HG, Steel D, Fleischer S, Seidel D, Kurz R, Vinz S, Dahlenborg K, Sartipy P, Robitzki AA.
PLoS One. 2013 Jul 8;8(7):e68971. doi: 10.1371/journal.pone.0068971.

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20 juin 2013
19:00 E.S.T.

Gene correction of a Duchenne Muscular Dystrophy by Meganuclease-Enhanced Exon

Popplewell L, Koo T, Leclerc X, Duclert A, Mamchaoui K, Gouble A, Mouly V, Voit T, Pâques F, Cédrone F, Yáñez-Muñoz R.J, Dickson G.
Hum Gene Ther. 2013 Jul;24(7):692-701. doi: 10.1089/hum.2013.081.

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05 juin 2013
19:00 E.S.T.

Topics in Current Genetics, Volume 23, 2013 - Chapter 14: Bio-applications derived from site-directed genome modification technologies

Delenda C, Paris S, Arnould S, Balbirnie E, Cabaniols J-P.
Publisher: Stefan Hohmann XIII, pp 353 – 384., 6 in color 2013

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Publications scientifiques

Expression, purification, crystallization and preliminary X-ray diffraction analysis of the novel modular DNA-binding protein BurrH in its apo form and in complex with its target DNA

Can stem-cell-derived models revolutionize drug discovery?

megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering

Targeted gene therapy of Xeroderma Pigmentosum cells using meganucleases and TALEN™

Structure of the AvrBs3-DNA complex provides new insights into the initial thymine-recognition mechanism

Genome engineering with TAL-effector Nucleases and Alternative Modular Nuclease Technologies

Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells

A Novel 3D Label-Free Monitoring System of hES-Derived Cardiomyocyte Clusters: A Step Forward to In Vitro Cardiotoxicity Testing

Gene correction of a Duchenne Muscular Dystrophy by Meganuclease-Enhanced Exon

Topics in Current Genetics, Volume 23, 2013 - Chapter 14: Bio-applications derived from site-directed genome modification technologies