Scientific publications

Preclinical Evidence of an Allogeneic Dual CD20xCD22 CAR to Target a Broad Spectrum of Patients with B-cell Malignancies

Beatriz Aranda-Orgilles ; Isabelle Chion-Sotinel ; Jordan Skinner ; Steven Grudman ; Ben Mumford ; Chantel Dixon ; Jorge Postigo Fernandez ; Piril Erler ; Phillipe Duchateau ; Agnes Gouble ; Roman Galetto ; Laurent Poirot
Cancer Immunology Research
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Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy

Shipra Das, Julien Valton, Philippe Duchateau, Laurent Poirot
Frontiers in Immunology
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Efficient multitool/multiplex gene engineering with TALE-BE

Alex Boyne, Alexandre Juillerat, Sylvain Pulicani, Maria Feola, Diane Tkach, Robert Hong, Aymeric Duclert, Philippe Duchateau
Frontiers in Bioengineering and Biotechnology
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Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing

Julien Valton, Shipra Das, Siumin Jo
Nature Communications
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Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells

Roman Galetto, Agnès Gouble
Nature Communications
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Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia

Roman Galetto, Agnès Gouble
Nature Communications
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Straightforward Generation of Ultrapure Off-the-Shelf Allogeneic CAR-T Cells

Alexandre Juillerat, Diane Tkach, Ming Yang, Alex Boyne, Julien Valton, Laurent Poirot and Philippe Duchateau
Frontiers in Bioengineering and Biotechnology June 25, 2020
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Allogeneic FLT3 CAR T cells with an off-switch exhibit potent activity against acute myeloid leukemia and can be depleted to expedite bone marrow recovery

Cesar Sommer, Hsin-Yuan Cheng, Duy Nguyen, Danielle Dettling, Yik Andy Yeung, Janette Sutton, Moustafa Hamze, Julien Valton, Julianne Smith, Ivana Djuretic, Javier Chaparro-Riggers, Barbra J. Sasu
Molecular Therapy June 15, 2020
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Off-the-shelf allogeneic CAR T cells: new development and current challenges

S. Depil, P. Duchateau, S. A. Grupp, G. Mufti and L. Poirot
Nature Review Drug Discovery January 3, 2020
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Repurposing Endogenous Immune Pathways to Tailor and Control Chimeric Antigen Receptor T-cell Functionality

Mohit Sachdeva, Brian W. Busser, Sonal Temburni, Billal Jahangiri, Anne-Sophie Gautron, Alan Maréchal, Alexandre Juillerat, Alan Williams, Stéphane Depil, Philippe Duchateau, Laurent Poirot and Julien Valton
Nature Communications November 2019
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