Press Release

Cellectis S.A. Grants Lexicon Genetics a Technology Sublicense

Romainville, France - November the 22^th, 2004 - Cellectis S.A., the rational genome engineering company, announced today that it entered into an agreement with Lexicon Genetics Incorporated by which Cellectis granted Lexicon a worldwide non-exclusive license under its patent family relating to a process for the specific replacement or insertion of a gene in an eukaryotic genome.
Through this agreement, Lexicon expands its intellectual property portfolio for creating and using genetically modified mice in its research activities towards the development of human therapeutic and diagnostic products.
Financial terms and conditions of the agreement were not disclosed.

Isabelle Pelletier-Bressac, Vice President Business Development of Cellectis commented "With Lexicon Genetics as an additional licensee, we have, from all the world-wide biotech and biopharmaceutical leaders working with engineered mice, the recognition of the strength and relevance of our patents." She added, "We are very pleased that Lexicon chose to add our technology to its proprietary gene targeting technology for use in its research and discovery programs".

Cellectis SA (www.cellectis.com) was founded in 1999, as a spin-off from the Institut Pasteur. Today, Cellectis is the world leader in applying the technology of Meganuclease Recombination Systems to in vivo genome engineering and genome surgery. The company is focused on the research and development of custom-made Meganucleases for in vivo DNA interventions and also provides new tools for rational reverse genetics and targeted recombination. Cellectis develops Meganucleases that can induce unique site-directed double-strand breaks in a living cell, and can be used for biotechnological and therapeutical applications. The company is focusing on bringing "genome surgery" to clinic as a genuine new molecular medicine approach.
As of today Cellectis has entered into 28 deals on its Genome Engineering technologies.

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