| January 2000 | André Choulika and David Sourdive found Cellectis. |
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| June 2000 | The company obtains licenses to six Pasteur Institute patent portfolios. The Pasteur Institute becomes a company shareholder. |
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| November 2000 | Kaminvest Holding (Business Angel) becomes a company shareholder (equity increase of 3.8 million euros in two rounds). |
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| November 2000 | The company moves into the Pasteur Institute's BioTop company incubator in Paris's 15th arrondissement. |
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| August 2001 | Zentaris signs a license agreement with the company in the field of cancer. |
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| October 2001 | GenOway signs a license agreement with the company in the field of animal models. |
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| January 2002 | Constitution of the Scientific Advisory Board, chaired by Professor François Jacob, winner of the Nobel Prize for Medicine. |
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| May 2002 | BankInvest Biomedical Venture, AGF Private Equity, Odyssée Venture and Edmond de Rothschild Investment Partners become company shareholders (equity increase of 8 million euros). |
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| November 2002 | Pioneer Hi-Bred International - DuPont signs a license agreement with the company in the field of meganucleases applied to corn. |
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| Mars 2003 | BASF Plant Science signs a license agreement with the company in the field of meganucleases applied to plant science. |
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| June 2003 | Publication of an article in Nucleic Acids Research on the production of synthetic hybrid meganucleases, constituting the first step worldwide in implementation of this technology. |
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| December 2003 | Regeneron Pharmaceuticals Inc. signs a license agreement with the company in the field of animal models. |
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| February 2004 | The company moves its corporate office and labs from the BioTop incubator in Paris to the Biocitech campus in Romainville (in the Seine Saint-Denis county, just north of Paris). |
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| April 2004 | Lexicon Genetics Inc. signs a license agreement with the company in the field of animal models. |
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| June 2005 | BankInvest Biomedical Venture, AGF Private Equity, Odyssée Venture and Edmond de Rothschild Investment Partners make an additional 5.6 million euro investment in the company. |
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| September 2005 | Biogen Idec signs an collaboration agreement with the company on the synthesis of custom meganucleases for use in protein production. |
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| November 2005 | Publication of an article in Nucleic Acids Research on the production method for the custom meganucleases designed by the company. |
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| December 2005 | TransKaryotic Therapies signs a license agreement with the company in the field of protein production. |
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| January 2006 | Publication of an initial article in the Journal of Molecular Biology on the large-scale production of custom meganucleases (validating the company's commercial potential). |
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| March 2006 | Publication in the Journal of Gene Medicine of an article on the first known experiment in in vivo meganuclease-based genome surgery (in the animal). |
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| June 2006 | Bayer BioScience signs a collaboration agreement with the company on custom meganucleases in the field of plant science. |
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| July 2006 | Lexicon Genetics Inc. signs a cross-licensing agreement with the company in the field of homologous recombination. |
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| September 2006 | The company produces its first therapeutically-focused meganuclease recombination systems (MRSs). |
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| November 2006 | The company achieves an annual production capacity of 8 MRSs. |
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| December 2006 | Registration of its Document de Base with the AMF in the context of the Company's contemplated initial public offering on the Alternext market of Euronext Paris. |
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| January 2007 | Publication of a Journal Nucleic Acids Research (NAR) article on artificial homing endonuclease. |
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| 23 January 2007 | Launch of its initial public offering on the Alternext market of Euronext Paris. Guide price: between ¤8.90 and ¤10.25 per share |
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| 6 February 2007 | Success of its initial public offering on the Alternext market of Euronext Paris. The offer price is set at ¤10.25 per share
Demand from institutional investors was over 6 times the number of shares offered |
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| 5 March 2007 | Full exercise of the greenshoe in the context of its initial public offering on the Alternext market of Euronext Paris. |
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| 19 March 2007 | Cellectis S.A. announces the publication of a Current Gene Therapy article on Meganucleases and its Perspectives for Gene Therapy. |
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| 3 April 2007 | Celonic sign a commercial license agreement following key milestone in meganuclease-mediated cell line engineering for biomanufacturing. |
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